Giorgio Casari Selected Research

m-AAA proteases

1/2019	Mice harbouring a SCA28 patient mutation in AFG3L2 develop late-onset ataxia associated with enhanced mitochondrial proteotoxicity.
1/2007	Variable and tissue-specific subunit composition of mitochondrial m-AAA protease complexes linked to hereditary spastic paraplegia.
11/2003	Loss of m-AAA protease in mitochondria causes complex I deficiency and increased sensitivity to oxidative stress in hereditary spastic paraplegia.

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Giorgio Casari Research Topics

Disease

7	Epilepsy (Aura) 01/2020 - 07/2003
5	COVID-19 01/2022 - 10/2020
5	Migraine with Aura (Familial Hemiplegic Migraine) 09/2019 - 11/2005
3	Pneumonia (Pneumonitis) 01/2021 - 10/2020
3	Hereditary Spastic Paraplegia 11/2020 - 11/2003
3	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2019 - 01/2015
2	Migraine Disorders (Migraine) 01/2021 - 01/2016
2	familial type 2 Hemiplegic migraine 01/2016 - 06/2011
2	Spinocerebellar Ataxias (Spinocerebellar Ataxia) 01/2015 - 08/2004
2	Ataxia (Dyssynergia) 01/2015 - 08/2004
2	Autosomal Dominant Nocturnal Frontal Lobe Epilepsy 01/2014 - 03/2009
2	Parkinsonian Disorders (Parkinsonism) 09/2009 - 11/2005
2	Insulin Resistance 05/2008 - 05/2003
2	Cardiovascular Diseases (Cardiovascular Disease) 05/2008 - 05/2003
2	Seizures (Absence Seizure) 08/2006 - 11/2005
1	Asymptomatic Infections 01/2021
1	Paraplegia (Spastic Paraplegia) 11/2020
1	Neuroinflammatory Diseases 11/2020
1	Intellectual Disability (Idiocy) 01/2020
1	Dystonia (Limb Dystonia) 01/2019
1	Spinocerebellar ataxia 28 01/2019
1	Movement Disorders (Movement Disorder) 01/2019
1	Ocular Albinism 02/2014
1	Starvation 08/2012
1	Parkinson Disease (Parkinson's Disease) 09/2009
1	Cerebellar Diseases (Cerebellar Syndrome) 07/2009
1	Pathologic Constriction (Stenosis) 05/2008
1	Hyperinsulinism (Hyperinsulinemia) 05/2008
1	Hyperemia 05/2008
1	Unstable Angina 05/2008
1	Atherosclerosis 05/2008
1	Vomiting 05/2007
1	Frontal Lobe Epilepsy (Epilepsy, Supplementary Motor) 08/2006
1	Somnambulism (Sleepwalking) 08/2006
1	Epileptic Syndromes 08/2006
1	Fibrosis (Cirrhosis) 12/2004
1	Juvenile gout 12/2004
1	Kidney Diseases (Kidney Disease) 12/2004
1	Hyperuricemia 12/2004
1	Renal Insufficiency (Renal Failure) 12/2004
1	Nephrolithiasis 12/2004
1	Hypercalciuria 12/2004
1	Gliosis 08/2004
1	Cerebellar Ataxia (Dysmetria) 08/2004
1	Dementia (Dementias) 08/2004
1	Diabetic Nephropathies (Diabetic Nephropathy) 06/2003
1	Essential Hypertension 06/2003
1	Type 2 Diabetes Mellitus (MODY) 05/2003

Drug/Important Bio-Agent (IBA)

5	AutoantibodiesIBA 01/2022 - 10/2020
5	Adenosine Triphosphatases (ATPase)IBA 09/2019 - 11/2005
4	Glutamic Acid (Glutamate)FDA Link 01/2021 - 01/2015
4	Protein Isoforms (Isoforms)IBA 01/2018 - 06/2003
3	m-AAA proteasesIBA 01/2019 - 11/2003
3	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)IBA 01/2014 - 08/2006
2	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2019 - 07/2009
2	Ceftriaxone (Ceftriaxon)FDA LinkGeneric 01/2016 - 01/2015
2	Nitric Oxide Synthase Type III (Endothelial Nitric Oxide Synthase)IBA 05/2008 - 05/2003
1	CytokinesIBA 01/2021
1	Prednisolone (Predate)FDA LinkGeneric 01/2021
1	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 01/2021
1	BenzodiazepinesIBA 11/2020
1	Mitochondrial Proteins (Mitochondrial Protein)IBA 11/2020
1	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA 11/2020
1	Bz-423IBA 11/2020
1	InterferonsIBA 10/2020
1	Immunoglobulin G (IgG)IBA 10/2020
1	Peptide Elongation Factors (Elongation Factor)IBA 01/2020
1	AntioxidantsIBA 01/2019
1	Peptide Hydrolases (Proteases)FDA Link 01/2015
1	LactamsIBA 01/2015
1	Anti-Bacterial Agents (Antibiotics)IBA 01/2015
1	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 02/2014
1	Pharmaceutical PreparationsIBA 01/2014
1	Carbamazepine (Tegretol)FDA LinkGeneric 01/2014
1	Adrenergic Agents (Adrenergic Drugs)IBA 01/2014
1	Histone Deacetylase InhibitorsIBA 08/2012
1	Amino Acids FDA Link 08/2012
1	ChromatinIBA 08/2012
1	Histone Deacetylases (Histone Deacetylase)IBA 08/2012
1	RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA 08/2012
1	Genetic Markers (Genetic Marker)IBA 09/2009
1	AdiponectinIBA 05/2008
1	Glucose (Dextrose)FDA LinkGeneric 05/2008
1	AdipokinesIBA 05/2008
1	LeptinIBA 05/2008
1	DiureticsIBA 05/2007
1	Cholinergic ReceptorsIBA 08/2006
1	Phosphotransferases (Kinase)IBA 11/2005
1	CalciumIBA 12/2004
1	Cysteine (L-Cysteine)FDA Link 12/2004
1	UromodulinIBA 12/2004
1	TATA-Box Binding Protein (TATA-Binding Protein)IBA 08/2004
1	AntibodiesIBA 08/2004
1	Metalloproteases (Metalloproteinases)IBA 11/2003
1	Ion Channels (Ion Channel)IBA 07/2003
1	Mitochondrial DNA (mtDNA)IBA 08/2002
1	DNA Polymerase gammaIBA 08/2002

Therapy/Procedure

1	Therapeutics 11/2020
1	Electrodes (Electrode) 01/2014
1	Stents 05/2008